Fluorometabolite biosynthesis and enzymology

     18F PET Chemistry

Fluorine in Biology

     Effect of multiple fluorines on aliphatic chains and rings

     Liquid Crystal applications

Multivicinal Fluorine

Motifs

     Stereoelectronic effects

     Conformational effects

     Stereoselective synthesis of C–F bonds

Synthesis and properties

of C–F in organic chemistry

Research Areas

Our research has a strong focus on organo-fluorine chemistry, and particularly organo-fluorine chemistry focused on bioorganic and chemical biology research. We are interested in the influence of the fluorine atom on the conformation and behaviour of biomolecules.

This program benefits significantly from small molecule X-ray crystallography with Prof. Alexandra Slawin at St Andrews.

We have a strong interest in synthetic organic chemistry and we are focussing on the synthesis of new motifs in organofluorine chemistry which can be used in a variety of performance molecules.

We also have a strong interest in enzymatic fluorination (the fluorinase) and how that can be applied to biotechnological solutions, through molecular biology, towards the production of organisms that can produce organofluorine compounds by fermentation (eg. antibiotics)

Structural support for our enzymology has been strongly enhanced by our collaboration with Prof. Jim Naismith’s laboratory at St Andrews.