Fluorometabolite biosynthesis and enzymology
18F PET Chemistry
Fluorine in Biology
Effect of multiple fluorines on aliphatic chains and rings
Liquid Crystal applications
Stereoselective synthesis of C–F bonds
Synthesis and properties
of C–F in organic chemistry
Our research has a strong focus on organo-fluorine chemistry, and particularly organo-fluorine chemistry focused on bioorganic and chemical biology research. We are interested in the influence of the fluorine atom on the conformation and behaviour of biomolecules.
This program benefits significantly from small molecule X-ray crystallography with Prof. Alexandra Slawin at St Andrews.
We have a strong interest in synthetic organic chemistry and we are focussing on the synthesis of new motifs in organofluorine chemistry which can be used in a variety of performance molecules.
We also have a strong interest in enzymatic fluorination (the fluorinase) and how that can be applied to biotechnological solutions, through molecular biology, towards the production of organisms that can produce organofluorine compounds by fermentation (eg. antibiotics)
Structural support for our enzymology has been strongly enhanced by our collaboration with Prof. Jim Naismith’s laboratory at St Andrews.